Experimental Oral Transmission of Atypical Scrapie to Sheep
نویسندگان
چکیده
منابع مشابه
Experimental Oral Transmission of Atypical Scrapie to Sheep
To investigate the possibility of oral transmission of atypical scrapie in sheep and determine the distribution of infectivity in the animals' peripheral tissues, we challenged neonatal lambs orally with atypical scrapie; they were then killed at 12 or 24 months. Screening test results were negative for disease-specific prion protein in all but 2 recipients; they had positive results for examin...
متن کاملExperimental transmission of atypical scrapie to sheep
BACKGROUND Active surveillance for transmissible spongiform encephalopathies in small ruminants has been an EU regulatory requirement since 2002. A number of European countries have subsequently reported cases of atypical scrapie, similar to previously published cases from Norway, which have pathological and molecular features distinct from classical scrapie. Most cases have occurred singly in ...
متن کاملTransmission of atypical scrapie to homozygous ARQ sheep
Two Cheviot ewes homozygous for the A136L141R154Q171 (AL141RQ) prion protein (PrP) genotype were exposed intracerebrally to brain pools prepared using four field cases of atypical scrapie from the United Kingdom. Animals were clinically normal until the end of the experiment, when they were culled 7 years post-inoculation. Limited accumulation of disease-associated PrP (PrPSc) was observed in t...
متن کاملPhenotype Shift from Atypical Scrapie to CH1641 following Experimental Transmission in Sheep
The interactions of host and infecting strain in ovine transmissible spongiform encephalopathies are known to be complex, and have a profound effect on the resulting phenotype of disease. In contrast to classical scrapie, the pathology in naturally-occurring cases of atypical scrapie appears more consistent, regardless of genotype, and is preserved on transmission within sheep homologous for th...
متن کاملExperimental oral transmission of United States origin scrapie to neonatal sheep.
Scrapie, a transmissible spongiform encephalopathy (TSE), is a naturally occurring fatal neurodegenerative disease of sheep and goats. The current study documents incubation periods, pathologic findings, and distribution of abnormal prion proteins (PrP(Sc)) by immunohistochemistry and Western blot in tissues of genetically susceptible and resistant neonatal lambs inoculated with pooled brain ho...
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ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 2011
ISSN: 1080-6040,1080-6059
DOI: 10.3201/eid1705.101654